| Gene Information | |
|---|---|
| Gene Name | MCM2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 904 |
| Protein Names | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000073111 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | P49736 |
| Gene Card | MCM2 |
| Uniprot ID | P49736 |
| Pfam | PF00493; PF12619; PF17855; PF14551; PF17207 |
| In ASD | no |
| Allosteric Prediction | yes (0.235572304) |
| Ortholog in Animals | Alpaca_ MCM2 ( ortholog_one2one ) Dog_ MCM2 ( ortholog_one2one ) GuineaPig_ MCM2 ( ortholog_one2one ) Macaque_ MCM2 ( ortholog_one2one ) Mouse_ Mcm2 ( ortholog_one2one ) Pig_ MCM2 ( ortholog_one2one ) Rat_ Mcm2 ( ortholog_one2one ) Rabbit_ MCM2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MCMDC2, MCM4, MCM9, MCM8, MCM5, MCM6, MCM7, MCM3 |
| Tissue | brain, testis |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003548(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4UUZ (X-ray 2.90A ) 5BNV (X-ray 2.79A ) 5BNX (X-ray 2.31A ) 5BO0 (X-ray 2.91A ) 5C3I (X-ray 3.50A ) 5JA4 (X-ray 2.42A ) 6XTX (EM 3.29A ) 6XTY (EM 6.77A ) 6YA7 (X-ray 1.67A ) 7CIZ (X-ray 1.80A ) 7CJ0 (X-ray 2.50A ) 7PFO (EM 3.20A ) 7PLO (EM 2.80A ) |
| DBSNP | rs375851208 rs3087452 rs2307314 rs1048225 rs3087450 rs13087457 rs2307311 rs2307313 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:8175912}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000250|UniProtKB:P55861}. |
| Mouse PG classification | NA |
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