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Gene Information
Gene Name
MCL1
Organism
Homo sapiens (Human)
Gene Length
350
Protein Names
Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT)
Target Name
induced myeloid leukemia cell differentiation protein mcl-1
Target Type
Clinical trial target
Gene Age
544 ( ENSG00000143384 )
Evolutionary Stage
Vertebrata
AlphaFoldDB
Q07820
Gene Card
MCL1
Uniprot ID
Q07820
Pfam
PF00452
In ASD
yes
Allosteric Prediction
yes (1.086010166)
Ortholog in Animals
Alpaca_ MCL1 ( ortholog_one2one )
Dog_ MCL1 ( ortholog_one2one )
GuineaPig_ MCL1 ( ortholog_one2one )
Macaque_ MCL1 ( ortholog_one2one )
Mouse_ Mcl1 ( ortholog_one2one )
Pig_ MCL1 ( ortholog_one2one )
Rat_ Mcl1 ( ortholog_one2many )
Rabbit_ MCL1 ( ortholog_one2one )
Ohnologs
NA
Paralogs
BCL2L10, BCL2A1, BAX, BAK1, BOK, BCL2L1, BCL2L2, BCL2
Tissue
NA
Tissue Specificity
NA
Pharmacological Animal Models
NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.042424(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
2KBW
(NMR
-
)
2MHS
(NMR
-
)
2NL9
(X-ray
1.55A
)
2NLA
(X-ray
2.80A
)
2PQK
(X-ray
2.00A
)
3D7V
(X-ray
2.03A
)
3IO9
(X-ray
2.40A
)
3KJ0
(X-ray
1.70A
)
3KJ1
(X-ray
1.94A
)
3KJ2
(X-ray
2.35A
)
3KZ0
(X-ray
2.35A
)
3MK8
(X-ray
2.32A
)
3PK1
(X-ray
2.49A
)
3TWU
(X-ray
1.80A
)
3WIX
(X-ray
1.90A
)
3WIY
(X-ray
2.15A
)
4BPI
(X-ray
1.98A
)
4BPJ
(X-ray
1.60A
)
4HW2
(X-ray
2.80A
)
4HW3
(X-ray
2.40A
)
4HW4
(X-ray
1.53A
)
4OQ5
(X-ray
2.86A
)
4OQ6
(X-ray
1.81A
)
4WGI
(X-ray
1.85A
)
4WMR
(X-ray
1.70A
)
4WMS
(X-ray
1.90A
)
4WMT
(X-ray
2.35A
)
4WMU
(X-ray
1.55A
)
4WMV
(X-ray
2.40A
)
4WMW
(X-ray
1.90A
)
4WMX
(X-ray
2.00A
)
4ZBF
(X-ray
2.20A
)
4ZBI
(X-ray
2.50A
)
5C3F
(X-ray
1.43A
)
5C6H
(X-ray
2.05A
)
5FC4
(X-ray
1.50A
)
5FDO
(X-ray
2.80A
)
5FDR
(X-ray
2.60A
)
5IEZ
(X-ray
2.60A
)
5IF4
(X-ray
2.39A
)
5JSB
(X-ray
2.74A
)
5KU9
(X-ray
2.20A
)
5LOF
(X-ray
2.20A
)
5MES
(X-ray
2.24A
)
5MEV
(X-ray
2.94A
)
5UUM
(X-ray
2.35A
)
5VKC
(X-ray
2.31A
)
5VX2
(X-ray
1.85A
)
5W89
(X-ray
1.42A
)
5W8F
(X-ray
1.85A
)
6B4L
(X-ray
2.25A
)
6B4U
(X-ray
1.95A
)
6BW2
(X-ray
2.75A
)
6BW8
(X-ray
2.90A
)
6FS0
(X-ray
2.25A
)
6FS1
(X-ray
1.60A
)
6FS2
(X-ray
2.55A
)
6MBD
(X-ray
1.95A
)
6MBE
(X-ray
2.25A
)
6NE5
(X-ray
1.85A
)
6O4U
(X-ray
1.70A
)
6O6F
(X-ray
1.60A
)
6O6G
(X-ray
2.40A
)
6OQB
(X-ray
1.60A
)
6OQC
(X-ray
1.80A
)
6OQD
(X-ray
1.48A
)
6OQN
(X-ray
1.70A
)
6OVC
(NMR
-
)
6P3P
(X-ray
1.61A
)
6QB3
(X-ray
1.90A
)
6QB4
(X-ray
2.38A
)
6QB6
(X-ray
2.24A
)
6QFC
(X-ray
1.96A
)
6QFI
(X-ray
2.40A
)
6QFM
(X-ray
2.00A
)
6QFQ
(X-ray
1.60A
)
6QGD
(X-ray
1.80A
)
6QXJ
(X-ray
1.70A
)
6QYK
(X-ray
2.30A
)
6QYL
(X-ray
2.20A
)
6QYN
(X-ray
2.50A
)
6QYO
(X-ray
2.10A
)
6QYP
(X-ray
2.20A
)
6QZ5
(X-ray
2.00A
)
6QZ6
(X-ray
1.90A
)
6QZ7
(X-ray
2.20A
)
6QZ8
(X-ray
2.15A
)
6QZB
(X-ray
2.00A
)
6STJ
(X-ray
2.20A
)
6U63
(X-ray
2.75A
)
6U64
(X-ray
2.55A
)
6U65
(X-ray
2.09A
)
6U67
(X-ray
1.84A
)
6U6F
(X-ray
2.90A
)
6UA3
(X-ray
1.55A
)
6UAB
(X-ray
2.10A
)
6UD2
(X-ray
1.70A
)
6UDI
(X-ray
1.94A
)
6UDT
(X-ray
1.50A
)
6UDU
(X-ray
1.75A
)
6UDV
(X-ray
1.35A
)
6UDX
(X-ray
1.70A
)
6UDY
(X-ray
1.70A
)
6VBX
(X-ray
1.95A
)
6YBG
(X-ray
2.10A
)
6YBJ
(X-ray
2.50A
)
6YBK
(X-ray
2.00A
)
6YBL
(X-ray
2.10A
)
6ZIE
(X-ray
2.30A
)
7NB4
(X-ray
1.90A
)
7NB7
(X-ray
2.82A
)
7XGE
(X-ray
2.38A
)
DBSNP
rs2737820
rs11580946
rs140449444
Subcellular location [CC]
Membrane {ECO:0000305};
Single-pass membrane protein {ECO:0000305}. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.
Mouse PG classification
NA
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