| Gene Information | |
|---|---|
| Gene Name | MCHR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 422 |
| Protein Names | Melanin-concentrating hormone receptor 1 (MCH receptor 1) (MCH-R1) (MCHR-1) (G-protein coupled receptor 24) (MCH-1R) (MCH1R) (MCHR) (SLC-1) (Somatostatin receptor-like protein) |
| Target Name | melanin-concentrating hormone receptor 1 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000128285 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q99705 |
| Gene Card | MCHR1 |
| Uniprot ID | Q99705 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (1.000684253) |
| Ortholog in Animals | Alpaca_ MCHR1 ( ortholog_one2one ) Dog_ MCHR1 ( ortholog_one2one ) GuineaPig_ MCHR1 ( ortholog_one2one ) Macaque_ MCHR1 ( ortholog_one2one ) Mouse_ Mchr1 ( ortholog_one2one ) Pig_ MCHR1 ( ortholog_one2one ) Rat_ Mchr1 ( ortholog_one2one ) Rabbit_ MCHR1 ( ortholog_one2one ) |
| Ohnologs | OPRD1, MCHR2, SSTR5, SSTR2 |
| Paralogs | MCHR2, TACR2, OR9A2, NPY1R, MTNR1B, OR11H6, OR11H7, OR11H4, OR9A1P, OR9G1, NPY2R, MTNR1A, GPR50, GPR75, OR11G2, GPR19, OR11A1, TACR1, TACR3, OR11H2, OR11H12, OR11H1, GPR83, PROKR2, PROKR1, GPR88, PRLHR, OR51F1, OR10X1, NPY5R, OR9A4, NPY4R2, NPY4R |
| Tissue | NA |
| Tissue Specificity | Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs117372135 rs112405400 rs133072 rs765971090 rs11914085 rs750210146 rs550313335 rs45439291 rs539260735 rs149604804 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
| click here to return to the previous page | |