| Gene Information | |
|---|---|
| Gene Name | MCH3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 303 |
| Protein Names | Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P55210 |
| Gene Card | CASP7 |
| Uniprot ID | P55210 |
| Pfam | NA |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain. {ECO:0000269|PubMed:8576161}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1F1J (X-ray 2.35A ) 1GQF (X-ray 2.90A ) 1I4O (X-ray 2.40A ) 1I51 (X-ray 2.45A ) 1K86 (X-ray 2.60A ) 1K88 (X-ray 2.70A ) 1KMC (X-ray 2.90A ) 1SHJ (X-ray 2.80A ) 1SHL (X-ray 3.00A ) 2QL5 (X-ray 2.34A ) 2QL7 (X-ray 2.40A ) 2QL9 (X-ray 2.14A ) 2QLB (X-ray 2.25A ) 2QLF (X-ray 2.80A ) 2QLJ (X-ray 2.60A ) 3EDR (X-ray 2.45A ) 3H1P (X-ray 2.61A ) 3IBC (X-ray 2.75A ) 3IBF (X-ray 2.50A ) 3R5K (X-ray 2.86A ) 4FDL (X-ray 2.80A ) 4FEA (X-ray 3.79A ) 4HQ0 (X-ray 3.00A ) 4HQR (X-ray 3.00A ) 4JB8 (X-ray 1.70A ) 4JJ8 (X-ray 2.94A ) 4JR1 (X-ray 2.15A ) 4JR2 (X-ray 1.65A ) 4LSZ (X-ray 2.26A ) 4ZVO (X-ray 2.85A ) 4ZVP (X-ray 2.50A ) 4ZVQ (X-ray 2.50A ) 4ZVR (X-ray 2.30A ) 4ZVS (X-ray 2.50A ) 4ZVT (X-ray 2.85A ) 4ZVU (X-ray 2.60A ) 5IC6 (X-ray 2.70A ) 5K20 (X-ray 2.20A ) 5V6U (X-ray 2.80A ) 5V6Z (X-ray 2.60A ) 7WZS (X-ray 3.60A ) |
| DBSNP | rs11555408 rs2227310 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:12824163, ECO:0000305|PubMed:21555521, ECO:0000305|PubMed:8576161}. Nucleus {ECO:0000269|PubMed:19617626, ECO:0000269|PubMed:21555521}. Secreted, extracellular space {ECO:0000250|UniProtKB:P97864}. Note=Following cleavage and activation by CASP1 or granzyme B (GZMB), secreted into the extracellular milieu by passing through the gasdermin-D (GSDMD) pores or perforin (PRF1) pore, respectively. {ECO:0000250|UniProtKB:P97864}. |
| Mouse PG classification | NA |
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