Gene Information
Gene NameMCF2L
OrganismHomo sapiens (Human)
Gene Length1137
Protein NamesGuanine nucleotide exchange factor DBS (DBL's big sister) (MCF2-transforming sequence-like protein)
Target NameNA
Target TypeNA
Gene Age454 ( ENSG00000126217 )
Evolutionary StageVertebrata
AlphaFoldDBO15068
Gene CardMCF2L
Uniprot IDO15068
PfamPF13716; PF00169; PF00621; PF07653; PF00435
In ASDno
Allosteric Predictionno (-0.301281582)
Ortholog in AnimalsAlpaca_ MCF2L ( ortholog_one2one )
Dog_ MCF2L ( ortholog_one2one )
GuineaPig_ MCF2L ( ortholog_one2one )
Macaque_ MCF2L ( ortholog_one2one )
Mouse_ Mcf2l ( ortholog_one2one )
Pig_ MCF2L ( ortholog_one2one )
Rat_ Mcf2l ( ortholog_one2one )
OhnologsMCF2, MCF2L2
ParalogsMCF2L2, VAV1, PLEKHN1, PLEKHG4, TIAM2, ARHGEF40, ARHGEF25, VAV2, VAV3, SPATA13, ARHGEF9, ARHGEF6, PLEKHG1, SESTD1, PLEKHG2, KIAA1755, PLEKHG4B, TIAM1, MCF2, KALRN, ARHGEF7, TRIO
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC][Isoform 5]: Cytoplasm {ECO:0000269|PubMed:15157669}. Cell membrane {ECO:0000269|PubMed:15157669};
Peripheral membrane protein {ECO:0000269|PubMed:15157669};
Cytoplasmic side {ECO:0000269|PubMed:15157669}.;
[Isoform 3]: Cytoplasm {ECO:0000269|PubMed:15157669}. Endomembrane system {ECO:0000269|PubMed:15157669}. Note=Interaction with membranes enriched in phosphoinositides is mediated by the CRAL-TRIO domain. {ECO:0000269|PubMed:15157669}.;
Cytoplasm {ECO:0000250|UniProtKB:Q64096}. Cell membrane {ECO:0000250|UniProtKB:Q64096};
Peripheral membrane protein {ECO:0000250|UniProtKB:Q64096};
Cytoplasmic side {ECO:0000250|UniProtKB:Q64096}.
Mouse PG classificationNA
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