| Gene Information | |
|---|---|
| Gene Name | PLK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 685 |
| Protein Names | Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 2) (PLK-2) (hPlk2) (Serine/threonine-protein kinase SNK) (hSNK) (Serum-inducible kinase) |
| Target Name | serine/threonine-protein kinase plk2 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000145632 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9NYY3 |
| Gene Card | PLK2 |
| Uniprot ID | Q9NYY3 |
| Pfam | PF00069; PF00659 |
| In ASD | no |
| Allosteric Prediction | yes (0.304888521) |
| Ortholog in Animals | Alpaca_ PLK2 ( ortholog_one2one ) Dog_ PLK2 ( ortholog_one2one ) GuineaPig_ PLK2 ( ortholog_one2one ) Macaque_ PLK2 ( ortholog_one2one ) Mouse_ Plk2 ( ortholog_one2one ) Pig_ PLK2 ( ortholog_one2one ) Rat_ Plk2 ( ortholog_one2one ) Rabbit_ PLK2 ( ortholog_one2one ) |
| Ohnologs | PLK3 |
| Paralogs | PLK3, PLK1, PLK5, PLK4 |
| Tissue | NA |
| Tissue Specificity | Expressed at higher level in the fetal lung, kidney, spleen and heart. {ECO:0000269|PubMed:11696980}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4I5M (X-ray 1.80A ) 4I5P (X-ray 1.74A ) 4I6B (X-ray 1.80A ) 4I6F (X-ray 2.90A ) 4I6H (X-ray 1.91A ) 4RS6 (X-ray 2.60A ) 4XB0 (X-ray 2.70A ) |
| DBSNP | rs1404394734 rs55768901 rs55645589 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:15242618, ECO:0000269|PubMed:19001868}. Cell projection, dendrite {ECO:0000250}. Note=Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase. |
| Mouse PG classification | NA |
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