| Gene Information | |
|---|---|
| Gene Name | RRM2B |
| Organism | Homo sapiens (Human) |
| Gene Length | 351 |
| Protein Names | Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2) |
| Target Name | ribonucleoside-diphosphate reductase subunit m2 b |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000048392 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q7LG56 |
| Gene Card | RRM2B |
| Uniprot ID | Q7LG56 |
| Pfam | PF00268 |
| In ASD | no |
| Allosteric Prediction | yes (0.182490433) |
| Ortholog in Animals | Alpaca_ RRM2B ( ortholog_one2one ) Dog_ RRM2B ( ortholog_one2one ) GuineaPig_ RRM2B ( ortholog_one2one ) Macaque_ RRM2B ( ortholog_one2one ) Mouse_ Rrm2b ( ortholog_one2one ) Pig_ RRM2B ( ortholog_one2one ) Rat_ Rrm2b ( ortholog_one2one ) Rabbit_ RRM2B ( ortholog_one2one ) |
| Ohnologs | RRM2 |
| Paralogs | RRM2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma. {ECO:0000269|PubMed:14583450}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2VUX (X-ray 2.80A ) 3HF1 (X-ray 2.60A ) 4DJN (X-ray 2.20A ) |
| DBSNP | rs387906892 rs515726182 rs515726184 rs267607025 rs267607024 rs515726191 rs121918308 rs515726196 rs121918309 rs182614164 rs515726198 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage. |
| Mouse PG classification | NA |
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