| Gene Information | |
|---|---|
| Gene Name | MCAM |
| Organism | Homo sapiens (Human) |
| Gene Length | 646 |
| Protein Names | Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000076706 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P43121 |
| Gene Card | MCAM |
| Uniprot ID | P43121 |
| Pfam | PF08205; PF00047; PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-0.295377663) |
| Ortholog in Animals | Alpaca_ MCAM ( ortholog_one2one ) Dog_ MCAM ( ortholog_one2one ) GuineaPig_ MCAM ( ortholog_one2one ) Macaque_ MCAM ( ortholog_one2one ) Mouse_ Mcam ( ortholog_one2one ) Pig_ MCAM ( ortholog_one2one ) Rat_ Mcam ( ortholog_one2one ) Rabbit_ MCAM ( ortholog_one2one ) |
| Ohnologs | BCAM, ALCAM |
| Paralogs | AGER, ALCAM, BCAM |
| Tissue | NA |
| Tissue Specificity | Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6LYN (X-ray 2.78A ) |
| DBSNP | rs34587557 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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