| Gene Information | |
|---|---|
| Gene Name | MC4R |
| Organism | Homo sapiens (Human) |
| Gene Length | 332 |
| Protein Names | Melanocortin receptor 4 (MC4-R) |
| Target Name | melanocortin receptor 4 |
| Target Type | Successful target |
| Gene Age | 680 ( ENSG00000166603 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P32245 |
| Gene Card | MC4R |
| Uniprot ID | P32245 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000213179) |
| Ortholog in Animals | Alpaca_ MC4R ( ortholog_one2one ) Dog_ MC4R ( ortholog_one2one ) GuineaPig_ Mc4r ( ortholog_one2one ) Macaque_ MC4R ( ortholog_one2one ) Mouse_ Mc4r ( ortholog_one2one ) Pig_ MC4R ( ortholog_one2one ) Rat_ Mc4r ( ortholog_one2one ) Rabbit_ MC4R ( ortholog_one2one ) |
| Ohnologs | MC3R, MC5R |
| Paralogs | S1PR1, S1PR5, S1PR2, S1PR3, S1PR4, LPAR1, LPAR2, LPAR3, GPR3, GPR119, GPR6, GPR12, CNR1, CNR2, MC3R, MC5R, MC2R, MC1R |
| Tissue | NA |
| Tissue Specificity | Brain, placental, and gut tissues. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 6W25 (X-ray 2.75A ) 7AUE (EM 2.97A ) 7F53 (EM 3.00A ) 7F54 (EM 3.00A ) 7F55 (EM 3.10A ) 7F58 (EM 3.10A ) 7PIU (EM 2.58A ) 7PIV (EM 2.86A ) |
| DBSNP | rs372794914 rs13447323 rs13447325 rs121913557 rs121913558 rs121913566 rs13447326 rs121913565 rs121913559 rs121913559 rs2229616 rs13447329 rs13447331 rs747681609 rs13447332 rs121913560 rs121913563 rs13447333 rs121913567 rs193922686 rs52820871 rs13447336 rs187152753 rs1057517991 rs121913562 rs121913561 rs121913564 rs13447337 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:25163632}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | HPG |
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