| Gene Information | |
|---|---|
| Gene Name | NPAS4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 802 |
| Protein Names | Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (Class E basic helix-loop-helix protein 79) (bHLHe79) (HLH-PAS transcription factor NXF) (PAS domain-containing protein 10) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000174576 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8IUM7 |
| Gene Card | NPAS4 |
| Uniprot ID | Q8IUM7 |
| Pfam | PF08447 |
| In ASD | no |
| Allosteric Prediction | no (-0.930770327) |
| Ortholog in Animals | Alpaca_ NPAS4 ( ortholog_one2one ) Dog_ NPAS4 ( ortholog_one2one ) GuineaPig_ NPAS4 ( ortholog_one2one ) Macaque_ NPAS4 ( ortholog_one2one ) Mouse_ Npas4 ( ortholog_one2one ) Pig_ NPAS4 ( ortholog_one2one ) Rat_ Npas4 ( ortholog_one2one ) Rabbit_ NPAS4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EPAS1, SIM1, NPAS1, SIM2, HIF1A, NPAS3, HIF3A |
| Tissue | brain.meninx |
| Tissue Specificity | Brain. {ECO:0000269|PubMed:14701734}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001990(Rat);0.02(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs79072452 rs905768 rs375915619 rs200310338 rs76159120 rs140299985 rs145746289 rs150700317 rs71457718 rs142965018 rs147463475 rs139929410 rs111848728 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:Q8BGD7, ECO:0000255|PROSITE-ProRule:PRU00981}. |
| Mouse PG classification | NA |
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