| Gene Information | |
|---|---|
| Gene Name | HUWE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 4374 |
| Protein Names | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000086758 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | NA |
| Gene Card | HUWE1 |
| Uniprot ID | Q7Z6Z7 |
| Pfam | PF06012; PF06025; PF00632; PF00627; PF14377; PF02825 |
| In ASD | no |
| Allosteric Prediction | yes (0.029823869) |
| Ortholog in Animals | Alpaca_ HUWE1 ( ortholog_one2one ) Dog_ HUWE1 ( ortholog_one2one ) GuineaPig_ HUWE1 ( ortholog_one2one ) Macaque_ HUWE1 ( ortholog_one2one ) Mouse_ Huwe1 ( ortholog_one2one ) Pig_ HUWE1 ( ortholog_one2one ) Rat_ Huwe1 ( ortholog_one2one ) Rabbit_ HUWE1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HERC4, NEDD4, HECTD1, NEDD4L, UBE3B, SMURF1, AREL1, UBR5, HERC2, HECW2, HERC3, WWP1, UBE3A, UBE3C, SMURF2, HACE1, HECTD2, HECTD4, ITCH, HECW1, WWP2, TRIP12, HERC5, HERC6 |
| Tissue | NA |
| Tissue Specificity | Weakly expressed in heart, brain and placenta but not in other tissues. Expressed in a number of cell lines, predominantly in those from colorectal carcinomas. {ECO:0000269|PubMed:15567145}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.021277(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2EKK (NMR - ) 2MUL (NMR - ) 3G1N (X-ray 2.60A ) 3H1D (X-ray 1.89A ) 5C6H (X-ray 2.05A ) 5LP8 (X-ray 2.70A ) 6FYH (X-ray 2.91A ) 6MIW (X-ray 2.00A ) 6PFL (X-ray 2.10A ) 7AZX (X-ray 2.25A ) 7JQ9 (EM 3.10A ) 7MOP (EM 3.30A ) 7MWD (EM 3.70A ) 7MWE (EM 3.40A ) 7MWF (EM 3.30A ) |
| DBSNP | rs1557036768 rs1057520538 rs1557036757 rs41307640 rs1557006903 rs1557006873 rs1556978515 rs1556955128 rs121918526 rs886041876 rs121918525 rs1556914274 rs1556913268 rs1556913258 rs1556913180 rs1556912828 rs121918527 rs1556910184 rs1556909287 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19713937}. Nucleus {ECO:0000269|PubMed:19713937}. Mitochondrion {ECO:0000269|PubMed:30217973}. Note=Mainly expressed in the cytoplasm of most tissues, except in the nucleus of spermatogonia, primary spermatocytes and neuronal cells (By similarity). Recruited to mitochondria following interaction with AMBRA1 (PubMed:30217973). {ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:30217973}. |
| Mouse PG classification | NA |
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