| Gene Information | |
|---|---|
| Gene Name | MBTPS2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 519 |
| Protein Names | Membrane-bound transcription factor site-2 protease (EC 3.4.24.85) (Endopeptidase S2P) (Sterol regulatory element-binding proteins intramembrane protease) (SREBPs intramembrane protease) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000012174 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | O43462 |
| Gene Card | MBTPS2 |
| Uniprot ID | O43462 |
| Pfam | PF02163 |
| In ASD | no |
| Allosteric Prediction | no (-0.563207677) |
| Ortholog in Animals | Alpaca_ MBTPS2 ( ortholog_one2one ) Dog_ MBTPS2 ( ortholog_one2one ) GuineaPig_ MBTPS2 ( ortholog_one2one ) Mouse_ Mbtps2 ( ortholog_one2one ) Rat_ Mbtps2 ( ortholog_one2one ) Rabbit_ MBTPS2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas. {ECO:0000269|PubMed:9659902}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs122468177 rs122468180 rs122468176 rs122468178 rs1555986267 rs587777306 rs122468179 rs1555986287 rs587776867 |
| Subcellular location [CC] | Membrane {ECO:0000305|PubMed:19361614}; Multi-pass membrane protein {ECO:0000305|PubMed:19361614}. Cytoplasm {ECO:0000269|PubMed:19361614}. |
| Mouse PG classification | NA |
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