| Gene Information | |
|---|---|
| Gene Name | MBP |
| Organism | Homo sapiens (Human) |
| Gene Length | 222 |
| Protein Names | Bone marrow proteoglycan (BMPG) (Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein (EMBP) (MBP) (Pregnancy-associated major basic protein)] |
| Target Name | myelin basic protein |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000197971 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P13727 |
| Gene Card | PRG2 |
| Uniprot ID | P13727 |
| Pfam | PF00059 |
| In ASD | no |
| Allosteric Prediction | yes (0.862503187) |
| Ortholog in Animals | Alpaca_ MBP ( ortholog_one2one ) Dog_ MBP ( ortholog_one2one ) GuineaPig_ MBP ( ortholog_one2one ) Macaque_ MBP ( ortholog_one2one ) Mouse_ Mbp ( ortholog_one2one ) Pig_ MBP ( ortholog_one2one ) Rat_ Mbp ( ortholog_one2one ) Rabbit_ MBP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | brain |
| Tissue Specificity | High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon. {ECO:0000269|PubMed:10491647, ECO:0000269|PubMed:7526035}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1H8U (X-ray 1.80A ) 2BRS (X-ray 2.20A ) 4QXX (X-ray 1.45A ) |
| DBSNP | rs142359007 rs536455 |
| Subcellular location [CC] | [Bone marrow proteoglycan]: Secreted. Note=The proform is secreted.; [Eosinophil granule major basic protein]: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core). |
| Mouse PG classification | NA |
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