| Gene Information | |
|---|---|
| Gene Name | MBP |
| Organism | Homo sapiens (Human) |
| Gene Length | 304 |
| Protein Names | Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein) |
| Target Name | myelin basic protein |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000197971 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P02686 |
| Gene Card | MBP |
| Uniprot ID | P02686 |
| Pfam | PF01669 |
| In ASD | no |
| Allosteric Prediction | yes (0.862503187) |
| Ortholog in Animals | Alpaca_ MBP ( ortholog_one2one ) Dog_ MBP ( ortholog_one2one ) GuineaPig_ MBP ( ortholog_one2one ) Macaque_ MBP ( ortholog_one2one ) Mouse_ Mbp ( ortholog_one2one ) Pig_ MBP ( ortholog_one2one ) Rat_ Mbp ( ortholog_one2one ) Rabbit_ MBP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | brain |
| Tissue Specificity | MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. {ECO:0000269|PubMed:7504278}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.014112(Mouse);0.001899(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1BX2 (X-ray 2.60A ) 1FV1 (X-ray 1.90A ) 1HQR (X-ray 3.20A ) 1K2D (X-ray 2.20A ) 1YMM (X-ray 3.50A ) 1ZGL (X-ray 2.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.; [Isoform 3]: Nucleus {ECO:0000269|PubMed:22609403}. Note=Targeted to nucleus in oligodendrocytes. |
| Mouse PG classification | NA |
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