| Gene Information | |
|---|---|
| Gene Name | MBD4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 580 |
| Protein Names | Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding endonuclease 1) (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000129071 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O95243 |
| Gene Card | MBD4 |
| Uniprot ID | O95243 |
| Pfam | PF01429 |
| In ASD | no |
| Allosteric Prediction | yes (0.639487936) |
| Ortholog in Animals | Alpaca_ MBD4 ( ortholog_one2one ) Dog_ MBD4 ( ortholog_one2one ) Macaque_ MBD4 ( ortholog_one2one ) Mouse_ Mbd4 ( ortholog_one2one ) Pig_ MBD4 ( ortholog_one2one ) Rat_ Mbd4 ( ortholog_one2one ) Rabbit_ MBD4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MECP2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2MOE (NMR - ) 3IHO (X-ray 2.70A ) 4DK9 (X-ray 2.76A ) 4E9E (X-ray 1.90A ) 4E9F (X-ray 1.79A ) 4E9G (X-ray 2.35A ) 4E9H (X-ray 3.00A ) 4EA4 (X-ray 2.00A ) 4EA5 (X-ray 2.14A ) 4LG7 (X-ray 2.50A ) 4OFA (X-ray 1.55A ) 4OFE (X-ray 2.15A ) 4OFH (X-ray 2.22A ) 5CHZ (X-ray 1.83A ) 6VJW (X-ray 2.02A ) 7KZ0 (X-ray 1.57A ) 7KZ1 (X-ray 1.62A ) 7KZG (X-ray 1.68A ) |
| DBSNP | rs2307296 rs10342 rs10342 rs2307289 rs140693 rs2307298 rs2307293 |
| Subcellular location [CC] | Nucleus. |
| Mouse PG classification | NA |
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