| Gene Information | |
|---|---|
| Gene Name | TPH2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 490 |
| Protein Names | Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Neuronal tryptophan hydroxylase) (Tryptophan 5-monooxygenase 2) |
| Target Name | tryptophan 5-hydroxylase 2 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000139287 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q8IWU9 |
| Gene Card | TPH2 |
| Uniprot ID | Q8IWU9 |
| Pfam | PF00351 |
| In ASD | no |
| Allosteric Prediction | yes (0.596455042) |
| Ortholog in Animals | Alpaca_ TPH2 ( ortholog_one2one ) Dog_ TPH2 ( ortholog_one2one ) GuineaPig_ TPH2 ( ortholog_one2one ) Macaque_ TPH2 ( ortholog_one2one ) Mouse_ Tph2 ( ortholog_one2one ) Pig_ TPH2 ( ortholog_one2one ) Rat_ Tph2 ( ortholog_one2one ) Rabbit_ TPH2 ( ortholog_one2one ) |
| Ohnologs | PAH, TPH1 |
| Paralogs | TPH1, TH, PAH |
| Tissue | NA |
| Tissue Specificity | Brain specific. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4V06 (X-ray 2.63A ) |
| DBSNP | rs199775778 rs34115267 rs78162420 rs75558144 rs17110563 rs120074176 rs2887147 rs120074175 rs1317926854 rs7488262 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
| click here to return to the previous page | |