Gene Information
Gene NameMBD1
OrganismHomo sapiens (Human)
Gene Length605
Protein NamesMethyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000141644 )
Evolutionary StageVertebrata
AlphaFoldDBQ9UIS9
Gene CardMBD1
Uniprot IDQ9UIS9
PfamPF01429; PF02008
In ASDno
Allosteric Predictionno (-0.345068583)
Ortholog in AnimalsAlpaca_ MBD1 ( ortholog_one2one )
Dog_ MBD1 ( ortholog_one2one )
GuineaPig_ MBD1 ( ortholog_one2one )
Macaque_ MBD1 ( ortholog_one2one )
Mouse_ Mbd1 ( ortholog_one2one )
Pig_ MBD1 ( ortholog_one2one )
Rat_ Mbd1 ( ortholog_one2one )
Rabbit_ MBD1 ( ortholog_one2one )
OhnologsNA
ParalogsMBD2, MBD3L1, MBD3L2B, MBD3L5, MBD3, MBD3L2, MBD3L3, MBD3L4
TissueNA
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:9207790}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1D9N  (NMR  -  )  1IG4  (NMR  -  )  4D4W  (NMR  -  )  5W9Q  (X-ray  1.80A  )  6D1T  (X-ray  2.25A  ) 
DBSNP rs125555 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14610093}. Nucleus matrix {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624}. Nucleus speckle {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624}. Chromosome {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14555760}. Note=Nuclear, in a punctate pattern (PubMed:12711603). Associated with euchromatic regions of the chromosomes, with pericentromeric regions on chromosome 1 and with telomeric regions from several chromosomes (PubMed:10648624, PubMed:10454587). {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12711603}.
Mouse PG classificationNA
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