| Gene Information | |
|---|---|
| Gene Name | TTYH2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 534 |
| Protein Names | Protein tweety homolog 2 (hTTY2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000141540 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9BSA4 |
| Gene Card | TTYH2 |
| Uniprot ID | Q9BSA4 |
| Pfam | PF04906 |
| In ASD | no |
| Allosteric Prediction | no (-0.377264366) |
| Ortholog in Animals | Alpaca_ TTYH2 ( ortholog_one2one ) Dog_ TTYH2 ( ortholog_one2one ) GuineaPig_ TTYH2 ( ortholog_one2one ) Macaque_ TTYH2 ( ortholog_one2one ) Mouse_ Ttyh2 ( ortholog_one2one ) Pig_ TTYH2 ( ortholog_one2one ) Rat_ Ttyh2 ( ortholog_one2one ) Rabbit_ TTYH2 ( ortholog_one2one ) |
| Ohnologs | TTYH1, TTYH3 |
| Paralogs | TTYH1, TTYH3 |
| Tissue | NA |
| Tissue Specificity | Expressed at higher level in brain and testis and at lower levels in heart, ovary, spleen and peripheral blood leukocytes. Up-regulated in 13 of 16 renal cell carcinoma samples examined. Up-regulated in colon carcinoma. {ECO:0000269|PubMed:11597145, ECO:0000269|PubMed:17569141}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7P54 (EM 3.30A ) 7P5M (EM 3.92A ) |
| DBSNP | rs11538875 rs11538876 rs35682745 rs35999669 rs9892705 rs12600564 rs9899862 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Mouse PG classification | NA |
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