| Gene Information | |
|---|---|
| Gene Name | MAT1A |
| Organism | Homo sapiens (Human) |
| Gene Length | 395 |
| Protein Names | S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Methionine adenosyltransferase I/III) (MAT-I/III) |
| Target Name | s-adenosylmethionine synthase isoform type-1 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000151224 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q00266 |
| Gene Card | MAT1A |
| Uniprot ID | Q00266 |
| Pfam | PF02773; PF02772; PF00438 |
| In ASD | no |
| Allosteric Prediction | yes (1.139043666) |
| Ortholog in Animals | Alpaca_ MAT1A ( ortholog_one2one ) Dog_ MAT1A ( ortholog_one2one ) GuineaPig_ MAT1A ( ortholog_one2one ) Macaque_ MAT1A ( ortholog_one2one ) Mouse_ Mat1a ( ortholog_one2one ) Pig_ MAT1A ( ortholog_one2one ) Rat_ Mat1a ( ortholog_one2one ) |
| Ohnologs | MAT2A |
| Paralogs | MAT2A |
| Tissue | liver |
| Tissue Specificity | Expressed in liver. {ECO:0000269|PubMed:8393662}. |
| Pharmacological Animal Models | 0.023713(Chimpanzee);0.001000(Mouse);0.001899(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2OBV (X-ray 2.05A ) 6SW5 (X-ray 2.35A ) 6SW6 (X-ray 2.85A ) |
| DBSNP | rs118204002 rs1143693 rs773267230 rs118204005 rs72558181 rs118204004 rs118204001 rs118204006 rs138742870 rs118204003 rs1170028069 |
| Subcellular location [CC] | NA |
| Mouse PG classification | LPG |
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