| Gene Information | |
|---|---|
| Gene Name | MASP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 686 |
| Protein Names | Mannan-binding lectin serine protease 2 (EC 3.4.21.104) (MBL-associated serine protease 2) (Mannose-binding protein-associated serine protease 2) (MASP-2) [Cleaved into: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain] |
| Target Name | mannan-binding lectin serine protease-2 |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000009724 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O00187 |
| Gene Card | MASP2 |
| Uniprot ID | O00187 |
| Pfam | PF00431; PF07645; PF00084; PF00089 |
| In ASD | no |
| Allosteric Prediction | yes (0.245573453) |
| Ortholog in Animals | Alpaca_ MASP2 ( ortholog_one2one ) Alpaca_ MASP2 ( ortholog_one2many ) Dog_ MASP2 ( ortholog_one2one ) Macaque_ MASP2 ( ortholog_one2one ) Mouse_ Masp2 ( ortholog_one2one ) Pig_ MASP2 ( ortholog_one2one ) Rat_ Masp2 ( ortholog_one2one ) |
| Ohnologs | MASP1, C1R, C1S |
| Paralogs | PRRG2, MASP1 |
| Tissue | liver |
| Tissue Specificity | Plasma. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.037642(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1Q3X (X-ray 2.23A ) 1SZB (X-ray 2.50A ) 1ZJK (X-ray 2.18A ) 3TVJ (X-ray 1.28A ) 4FXG 5JPM (X-ray 3.75A ) |
| DBSNP | rs61735600 rs147270785 rs72550870 rs56392418 rs141145402 rs2273343 rs12711521 rs2273346 rs61735594 rs12085877 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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