| Gene Information | |
|---|---|
| Gene Name | SLCO1C1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 712 |
| Protein Names | Solute carrier organic anion transporter family member 1C1 (Organic anion transporter 1C1) (OATP1C1) (Organic anion transporter F) (OATP-F) (Organic anion transporter polypeptide-related protein 5) (OAT-RP-5) (OATP-RP5) (Organic anion-transporting polypeptide 14) (OATP-14) (Solute carrier family 21 member 14) (Thyroxine transporter) |
| Target Name | organic anion transporter f |
| Target Type | Literature-reported target |
| Gene Age | 680 ( ENSG00000139155 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NYB5 |
| Gene Card | SLCO1C1 |
| Uniprot ID | Q9NYB5 |
| Pfam | PF07648; PF03137 |
| In ASD | no |
| Allosteric Prediction | no (-0.03293007) |
| Ortholog in Animals | Alpaca_ SLCO1C1 ( ortholog_one2one ) Dog_ SLCO1C1 ( ortholog_one2one ) GuineaPig_ SLCO1C1 ( ortholog_one2one ) Macaque_ SLCO1C1 ( ortholog_one2one ) Mouse_ Slco1c1 ( ortholog_one2one ) Pig_ SLCO1C1 ( ortholog_one2one ) Rat_ Slco1c1 ( ortholog_one2one ) Rabbit_ SLCO1C1 ( ortholog_one2one ) |
| Ohnologs | SLCO3A1, SLCO2B1, SLCO5A1, SLCO2A1 |
| Paralogs | SLCO5A1, SLCO6A1, SLCO4C1, SLCO4A1, SLCO1B1, SLCO1B3, SLCO1A2, SLCO2B1, SLCO2A1, SLCO3A1 |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | Highly expressed in brain and in Leydig cells in testis (PubMed:12351693). Localized in nests of Leydig cells (at protein level) (PubMed:12351693). Expressed in choroid plexus (at protein level) (PubMed:18687783). Not strongly enriched in cerebral microvessels (PubMed:18687783). {ECO:0000269|PubMed:12351693, ECO:0000269|PubMed:18687783}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12351693, ECO:0000269|PubMed:18687783}; Multi-pass membrane protein {ECO:0000269|PubMed:18687783}. Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus. {ECO:0000269|PubMed:18687783}. |
| Mouse PG classification | NA |
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