| Gene Information | |
|---|---|
| Gene Name | NPSR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 371 |
| Protein Names | Neuropeptide S receptor (G-protein coupled receptor 154) (G-protein coupled receptor PGR14) (G-protein coupled receptor for asthma susceptibility) |
| Target Name | neuropeptide s receptor |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000187258 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6W5P4 |
| Gene Card | NPSR1 |
| Uniprot ID | Q6W5P4 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (1.291241929) |
| Ortholog in Animals | Alpaca_ NPSR1 ( ortholog_one2one ) Dog_ NPSR1 ( ortholog_one2one ) GuineaPig_ NPSR1 ( ortholog_one2one ) Macaque_ NPSR1 ( ortholog_one2one ) Mouse_ Npsr1 ( ortholog_one2one ) Pig_ NPSR1 ( ortholog_one2one ) Rat_ Npsr1 ( ortholog_one2one ) Rabbit_ NPSR1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 4 is ubiquitous; it is detected in glandular epithelia of bronchus, stomach, small intestine, colon, uterus, esophagus, spleen, kidney, pancreas, prostate and breast. Isoform 1 is detected in uterus, colon and prostate, and in the smooth muscle cell layer in bronchial and arterial walls (at protein level) (PubMed:15947423). Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epithelial cells, its expression is consistently stronger in asthma patients. {ECO:0000269|PubMed:15073379, ECO:0000269|PubMed:15947423}. |
| Pharmacological Animal Models | 0.310614(Chimpanzee);0.332490(Mouse);NULL(Rat);0.003200(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs324981 rs35436513 rs325465 rs34705969 rs35537374 rs727162 rs10270766 rs6972158 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:15947423, ECO:0000269|PubMed:16790440}; Multi-pass membrane protein {ECO:0000305}.; [Isoform 3]: Cell membrane {ECO:0000269|PubMed:15947423}; Multi-pass membrane protein {ECO:0000305}.; [Isoform 4]: Cell membrane {ECO:0000269|PubMed:15947423}; Multi-pass membrane protein {ECO:0000305}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:15947423}.; [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:15947423}.; [Isoform 6]: Cytoplasm {ECO:0000269|PubMed:15947423}.; [Isoform 7]: Cytoplasm {ECO:0000269|PubMed:15947423}.; [Isoform 9]: Cytoplasm {ECO:0000269|PubMed:15947423}. |
| Mouse PG classification | NA |
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