| Gene Information | |
|---|---|
| Gene Name | MARK3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 753 |
| Protein Names | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) |
| Target Name | microtubule affinity regulating kinase 3 |
| Target Type | Clinical trial target |
| Gene Age | 1064 ( ENSG00000075413 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P27448 |
| Gene Card | MARK3 |
| Uniprot ID | P27448 |
| Pfam | PF02149; PF00069; PF00627 |
| In ASD | no |
| Allosteric Prediction | yes (0.545611681) |
| Ortholog in Animals | Alpaca_ MARK3 ( ortholog_one2one ) Dog_ MARK3 ( ortholog_one2one ) GuineaPig_ MARK3 ( ortholog_one2one ) Macaque_ MARK3 ( ortholog_one2one ) Mouse_ Mark3 ( ortholog_one2one ) Pig_ MARK3 ( ortholog_one2one ) Rat_ Mark3 ( ortholog_one2one ) Rabbit_ MARK3 ( ortholog_one2one ) |
| Ohnologs | MARK4, MARK2, MARK1 |
| Paralogs | MARK2, MARK4, MARK1 |
| Tissue | heart, left.ventricle, mitral.valve, pancreas, pulmonary.valve, substantia.nigra |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2QNJ (X-ray 2.70A ) 3FE3 (X-ray 1.90A ) 7P1L (X-ray 1.95A ) |
| DBSNP | rs10137161 rs56305318 rs376395495 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:21145462}; Peripheral membrane protein {ECO:0000269|PubMed:21145462}. Cell projection, dendrite {ECO:0000269|PubMed:23666762}. Cytoplasm {ECO:0000269|PubMed:23666762}. |
| Mouse PG classification | NA |
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