| Gene Information | |
|---|---|
| Gene Name | MARK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 788 |
| Protein Names | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) |
| Target Name | serine/threonine-protein kinase mark2 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000072518 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q7KZI7 |
| Gene Card | MARK2 |
| Uniprot ID | Q7KZI7 |
| Pfam | PF02149; PF00069; PF00627 |
| In ASD | no |
| Allosteric Prediction | no (-0.216098483) |
| Ortholog in Animals | Alpaca_ MARK2 ( ortholog_one2one ) Dog_ MARK2 ( ortholog_one2one ) GuineaPig_ MARK2 ( ortholog_one2one ) Macaque_ MARK2 ( ortholog_one2one ) Mouse_ Mark2 ( ortholog_one2one ) Pig_ MARK2 ( ortholog_one2one ) Rat_ Mark2 ( ortholog_one2one ) Rabbit_ MARK2 ( ortholog_one2one ) |
| Ohnologs | MARK4, MARK3, MARK1 |
| Paralogs | MARK4, MARK1, MARK3 |
| Tissue | NA |
| Tissue Specificity | High levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney. {ECO:0000269|PubMed:9730619}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3IEC (X-ray 2.20A ) 5EAK (X-ray 2.80A ) 5KZ7 (X-ray 3.20A ) 5KZ8 (X-ray 3.21A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane; Peripheral membrane protein. Cytoplasm. Lateral cell membrane. Cytoplasm, cytoskeleton. Cell projection, dendrite {ECO:0000269|PubMed:23666762}. Cytoplasm {ECO:0000269|PubMed:23666762}. Note=Phosphorylation at Thr-596 by PRKCZ/aPKC and subsequent interaction with 14-3-3 protein YWHAZ promotes relocation from the cell membrane to the cytoplasm. |
| Mouse PG classification | NA |
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