Gene Information
Gene NameSLC26A3
OrganismHomo sapiens (Human)
Gene Length764
Protein NamesChloride anion exchanger (Down-regulated in adenoma) (Protein DRA) (Solute carrier family 26 member 3)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000091138 )
Evolutionary StageCellular_organisms
AlphaFoldDBP40879
Gene CardSLC26A3
Uniprot IDP40879
PfamPF01740; PF00916
In ASDno
Allosteric Predictionno (-0.299764446)
Ortholog in AnimalsAlpaca_ SLC26A3 ( ortholog_one2one )
Dog_ SLC26A3 ( ortholog_one2one )
GuineaPig_ SLC26A3 ( ortholog_one2one )
Macaque_ SLC26A3 ( ortholog_one2one )
Mouse_ Slc26a3 ( ortholog_one2one )
Pig_ SLC26A3 ( ortholog_one2one )
Rat_ Slc26a3 ( ortholog_one2one )
Rabbit_ SLC26A3 ( ortholog_one2one )
OhnologsSLC26A1, SLC26A2, SLC26A9
ParalogsSLC26A4, SLC26A6, SLC26A5, SLC26A7, SLC26A8, SLC26A1, SLC26A2, SLC26A9, SLC26A11
Tissuecolon, duodenum, rectum, appendix, gall.bladder, small.intestine, transverse.colon
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs10280704  rs386833479  rs121913030  rs386833480  rs386833481  rs386833481  rs386833483  rs386833484  rs386833487  rs386833488  rs386833489  rs34407351  rs386833491  rs386833444  rs386833446  rs1228273365  rs143839547  rs763669046  rs386833454  rs386833457  rs386833462  rs386833463  rs386833464  rs386833467  rs2301635  rs140426439  rs121913031  rs35342296 
Subcellular location [CC]Apical cell membrane {ECO:0000269|PubMed:22159084};
Multi-pass membrane protein {ECO:0000269|PubMed:22159084}. Membrane {ECO:0000250};
Multi-pass membrane protein {ECO:0000250}. Note=Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). {ECO:0000250}.
Mouse PG classificationHPG
click here to return to the previous page