| Gene Information | |
|---|---|
| Gene Name | DLL4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 685 |
| Protein Names | Delta-like protein 4 (Drosophila Delta homolog 4) (Delta4) |
| Target Name | delta-like protein 4 |
| Target Type | Clinical trial target |
| Gene Age | 950 ( ENSG00000128917 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9NR61 |
| Gene Card | DLL4 |
| Uniprot ID | Q9NR61 |
| Pfam | PF01414; PF00008; PF07657 |
| In ASD | no |
| Allosteric Prediction | no (-0.57120668) |
| Ortholog in Animals | Alpaca_ DLL4 ( ortholog_one2one ) Dog_ DLL4 ( ortholog_one2one ) GuineaPig_ DLL4 ( ortholog_one2one ) Macaque_ DLL4 ( ortholog_one2one ) Mouse_ Dll4 ( ortholog_one2one ) Pig_ DLL4 ( ortholog_one2one ) Rat_ Dll4 ( ortholog_one2one ) Rabbit_ DLL4 ( ortholog_one2one ) |
| Ohnologs | DLL1 |
| Paralogs | NOTCH4, JAG1, DNER, JAG2, DLL1 |
| Tissue | NA |
| Tissue Specificity | Expressed in vascular endothelium. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002657(Rat);0.08(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5MVX (X-ray 2.17A ) |
| DBSNP | rs796065350 rs796065348 rs796065351 rs796065349 rs796065347 rs796065346 rs796065345 |
| Subcellular location [CC] | Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Mouse PG classification | LPG |
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