| Gene Information | |
|---|---|
| Gene Name | MAPRE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 268 |
| Protein Names | Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000101367 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15691 |
| Gene Card | MAPRE1 |
| Uniprot ID | Q15691 |
| Pfam | PF00307; PF03271 |
| In ASD | no |
| Allosteric Prediction | no (-0.193630494) |
| Ortholog in Animals | Alpaca_ MAPRE1 ( ortholog_one2one ) Dog_ MAPRE1 ( ortholog_one2many ) Macaque_ MAPRE1 ( ortholog_one2one ) Mouse_ Mapre1 ( ortholog_one2one ) Pig_ MAPRE1 ( ortholog_one2one ) Rat_ Mapre1 ( ortholog_one2one ) Rabbit_ MAPRE1 ( ortholog_one2one ) |
| Ohnologs | MAPRE3, MAPRE2 |
| Paralogs | MAPRE3, MAPRE2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:10644998}. |
| Pharmacological Animal Models | 0.044499(Chimpanzee);0.059487(Mouse);NULL(Rat);0.022857(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1PA7 (X-ray 1.45A ) 1TXQ (X-ray 1.80A ) 1UEG (X-ray 2.40A ) 1VKA (X-ray 1.60A ) 1WU9 (X-ray 1.54A ) 1YIB (X-ray 1.80A ) 1YIG (X-ray 2.00A ) 2HKQ (X-ray 1.86A ) 2HL3 (X-ray 2.03A ) 2HL5 (X-ray 1.93A ) 2QJZ (X-ray 1.25A ) 2R8U (X-ray 1.35A ) 3GJO (X-ray 2.50A ) 3MTU (X-ray 2.10A ) 3MUD (X-ray 2.20A ) 3TQ7 (X-ray 2.30A ) 4XA1 (X-ray 3.20A ) 4XA3 (X-ray 2.55A ) 4XA6 (X-ray 3.42A ) 5JV3 (X-ray 2.01A ) 5JVM (X-ray 1.57A ) 5JVP (X-ray 2.10A ) 5JVR (X-ray 2.10A ) 5JVS (X-ray 2.25A ) 5JVU (X-ray 1.95A ) 5JX1 (X-ray 1.67A ) 5WLQ (X-ray 3.10A ) 6PF2 (X-ray 2.17A ) 6PFP (X-ray 2.20A ) 6YF5 (X-ray 1.83A ) 6YSH (X-ray 2.83A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10188731, ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23001180, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:9724749}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:14654843}. Golgi apparatus {ECO:0000269|PubMed:25217626}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23509069}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:34608293}. Note=Associated with the microtubule growing distal tips (PubMed:28814570). Recruitment to the Golgi apparatus requires the presence of PDE4DIP isoform 13/MMG8/SMYLE (PubMed:25217626). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:28814570}. |
| Mouse PG classification | NA |
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