| Gene Information | |
|---|---|
| Gene Name | SIK3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1321 |
| Protein Names | Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK) |
| Target Name | serine/threonine-protein kinase sik3 |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000160584 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9Y2K2 |
| Gene Card | SIK3 |
| Uniprot ID | Q9Y2K2 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.191949786) |
| Ortholog in Animals | Alpaca_ SIK3 ( ortholog_one2many ) Dog_ SIK3 ( ortholog_one2one ) GuineaPig_ SIK3 ( ortholog_one2one ) Macaque_ SIK3 ( ortholog_one2one ) Mouse_ Sik3 ( ortholog_one2one ) Pig_ SIK3 ( ortholog_one2one ) Rat_ Sik3 ( ortholog_one2one ) Rabbit_ SIK3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TSSK6, SNRK, SIK2, NIM1K, NUAK2, TSSK2, TSSK4, SIK1, PRKAA2, BRSK2, NUAK1, BRSK1, HUNK, PRKAA1, TSSK1B, MELK, TSSK3 |
| Tissue | NA |
| Tissue Specificity | Expressed in chondrocytes. {ECO:0000269|PubMed:30232230}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1565460853 rs376144593 rs11216163 rs12225230 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16306228}. Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ. {ECO:0000269|PubMed:16306228}. |
| Mouse PG classification | NA |
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