| Gene Information | |
|---|---|
| Gene Name | MAPKAP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 522 |
| Protein Names | Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1) |
| Target Name | target of rapamycin complex 2 mapkap1 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000119487 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9BPZ7 |
| Gene Card | MAPKAP1 |
| Uniprot ID | Q9BPZ7 |
| Pfam | PF16978; PF05422; PF16979 |
| In ASD | no |
| Allosteric Prediction | yes (0.839111494) |
| Ortholog in Animals | Alpaca_ MAPKAP1 ( ortholog_one2one ) Dog_ MAPKAP1 ( ortholog_one2one ) GuineaPig_ MAPKAP1 ( ortholog_one2one ) Macaque_ MAPKAP1 ( ortholog_one2one ) Mouse_ Mapkap1 ( ortholog_one2one ) Pig_ MAPKAP1 ( ortholog_one2one ) Rat_ Mapkap1 ( ortholog_one2one ) Rabbit_ MAPKAP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed, with highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:15988011}. |
| Pharmacological Animal Models | 0.083067(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 3VOQ (X-ray 2.00A ) 5ZCS (EM 4.90A ) 6ZWM (EM 3.20A ) 6ZWO (EM 3.00A ) 7LC1 (X-ray 2.35A ) 7LC2 (X-ray 2.70A ) 7PE7 (EM 3.41A ) 7PE8 (EM 3.20A ) 7PE9 (EM 3.70A ) 7VV8 (X-ray 1.70A ) 7VV9 (X-ray 1.60A ) 7VVB (X-ray 1.70A ) 7VVG (X-ray 1.70A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus. |
| Mouse PG classification | NA |
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