| Gene Information | |
|---|---|
| Gene Name | MAPK9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 424 |
| Protein Names | Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) |
| Target Name | stress-activated protein kinase jnk2 |
| Target Type | Preclinical target |
| Gene Age | >4290 ( ENSG00000050748 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P45984 |
| Gene Card | MAPK9 |
| Uniprot ID | P45984 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (1.213713175) |
| Ortholog in Animals | Alpaca_ MAPK9 ( ortholog_one2one ) Dog_ MAPK9 ( ortholog_one2one ) GuineaPig_ MAPK9 ( ortholog_one2one ) Macaque_ MAPK9 ( ortholog_one2one ) Mouse_ Mapk9 ( ortholog_one2one ) Pig_ MAPK9 ( ortholog_one2one ) Rat_ Mapk9 ( ortholog_one2one ) Rabbit_ MAPK9 ( ortholog_one2one ) |
| Ohnologs | MAPK8, MAPK10 |
| Paralogs | MAPK8, MAPK10, MAPK1, MAPK6, MAPK12, MAPK13, SRPK1, SRPK3, MAPK4, NLK, MAPK14, MAPK3, MOK, MAPK11, MAK, MAPK15, MAPK7, SRPK2, CILK1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 3E7O (X-ray 2.14A ) 3NPC (X-ray 2.35A ) 7CML (X-ray 2.15A ) 7N8T (X-ray 1.69A ) |
| DBSNP | rs35421153 rs35693958 rs55736180 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19675674}. Nucleus {ECO:0000269|PubMed:19675674}. Note=Colocalizes with POU5F1 in the nucleus. {ECO:0000250|UniProtKB:Q9WTU6}. |
| Mouse PG classification | NA |
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