| Gene Information | |
|---|---|
| Gene Name | MAPK8IP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 711 |
| Protein Names | C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1) |
| Target Name | jnk-interacting protein 1 peptide |
| Target Type | Patented-recorded target |
| Gene Age | 987 ( ENSG00000121653 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UQF2 |
| Gene Card | MAPK8IP1 |
| Uniprot ID | Q9UQF2 |
| Pfam | PF00640; PF14604 |
| In ASD | no |
| Allosteric Prediction | no (-0.329310652) |
| Ortholog in Animals | Alpaca_ MAPK8IP1 ( ortholog_one2one ) Dog_ MAPK8IP1 ( ortholog_one2one ) GuineaPig_ MAPK8IP1 ( ortholog_one2one ) Macaque_ MAPK8IP1 ( ortholog_one2one ) Mouse_ Mapk8ip1 ( ortholog_one2one ) Pig_ MAPK8IP1 ( ortholog_one2one ) Rat_ Mapk8ip1 ( ortholog_one2one ) |
| Ohnologs | MAPK8IP2 |
| Paralogs | MAPK8IP2, C1orf226, NOS1AP, NUMBL, NUMB, LDLRAP1, FAM43B, FAM43A, DAB2, GULP1, DAB1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in brain. Expressed in neurons, localizing to neurite tips in differentiating cells. Also expressed in the pancreas, testis and prostate. Low levels in heart, ovary and small intestine. Decreased levels in pancreatic beta cells sensitize cells to IL-1-beta-induced apoptosis. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.02963(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2G01 (X-ray 3.50A ) 2GMX (X-ray 3.50A ) 2H96 (X-ray 3.00A ) 3OXI (X-ray 2.20A ) 3PTG (X-ray 2.43A ) 3VUD (X-ray 3.50A ) 3VUG (X-ray 3.24A ) 3VUH (X-ray 2.70A ) 3VUI (X-ray 2.80A ) 3VUK (X-ray 2.95A ) 3VUL (X-ray 2.81A ) 3VUM (X-ray 2.69A ) 4E73 (X-ray 2.27A ) 4G1W (X-ray 2.45A ) 4H39 (X-ray 1.99A ) 4HYS (X-ray 2.42A ) 4HYU (X-ray 2.15A ) 4IZY (X-ray 2.30A ) 5LW1 (X-ray 3.20A ) 6FUZ (X-ray 2.70A ) 7NYK (X-ray 1.45A ) 7NYL (X-ray 1.95A ) 7NYM (X-ray 1.61A ) 7NYN (X-ray 1.54A ) 7NYO (X-ray 1.40A ) 7NZB (X-ray 1.96A ) |
| DBSNP | rs119489103 rs34420676 rs12295161 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum membrane. Mitochondrion membrane. Note=Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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