| Gene Information | |
|---|---|
| Gene Name | MAPK8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 427 |
| Protein Names | Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) |
| Target Name | mitogen-activated protein kinases |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000107643 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P45983 |
| Gene Card | MAPK8 |
| Uniprot ID | P45983 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (1.665419924) |
| Ortholog in Animals | Alpaca_ MAPK8 ( ortholog_one2one ) Dog_ MAPK8 ( ortholog_one2one ) GuineaPig_ MAPK8 ( ortholog_one2one ) Macaque_ MAPK8 ( ortholog_one2one ) Mouse_ Mapk8 ( ortholog_one2one ) Pig_ MAPK8 ( ortholog_one2one ) Rat_ Mapk8 ( ortholog_one2one ) Rabbit_ MAPK8 ( ortholog_one2one ) |
| Ohnologs | MAPK9, MAPK10 |
| Paralogs | MAPK1, MAPK6, MAPK12, MAPK13, SRPK1, SRPK3, MAPK4, NLK, MAPK14, MAPK3, MOK, MAPK11, MAK, MAPK15, MAPK7, SRPK2, MAPK9, CILK1, MAPK10 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.025(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1UKH (X-ray 2.35A ) 1UKI (X-ray 2.70A ) 2G01 (X-ray 3.50A ) 2GMX (X-ray 3.50A ) 2H96 (X-ray 3.00A ) 2NO3 (X-ray 3.20A ) 2XRW (X-ray 1.33A ) 2XS0 (X-ray 2.60A ) 3ELJ (X-ray 1.80A ) 3O17 (X-ray 3.00A ) 3O2M (X-ray 2.70A ) 3PZE (X-ray 2.00A ) 3V3V (X-ray 2.70A ) 3VUD (X-ray 3.50A ) 3VUG (X-ray 3.24A ) 3VUH (X-ray 2.70A ) 3VUI (X-ray 2.80A ) 3VUK (X-ray 2.95A ) 3VUL (X-ray 2.81A ) 3VUM (X-ray 2.69A ) 4AWI (X-ray 1.91A ) 4E73 (X-ray 2.27A ) 4G1W (X-ray 2.45A ) 4HYS (X-ray 2.42A ) 4HYU (X-ray 2.15A ) 4IZY (X-ray 2.30A ) 4L7F (X-ray 1.95A ) 4QTD (X-ray 1.50A ) 4UX9 (X-ray 2.34A ) 4YR8 (X-ray 2.40A ) 5LW1 (X-ray 3.20A ) 6F5E (X-ray 2.70A ) 6ZR5 (X-ray 2.70A ) |
| DBSNP | rs45483593 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21148294}. Nucleus {ECO:0000269|PubMed:21148294, ECO:0000269|PubMed:30878395}. Synapse {ECO:0000250|UniProtKB:P49185}. Note=In the cortical neurons, predominantly cytoplasmic and associated with the Golgi apparatus and endosomal fraction. Increased neuronal activity increases phosphorylated form at synapses (By similarity). Colocalizes with POU5F1 in the nucleus. {ECO:0000250|UniProtKB:P49185, ECO:0000250|UniProtKB:Q91Y86}. |
| Mouse PG classification | NA |
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