| Gene Information | |
|---|---|
| Gene Name | MNEI |
| Organism | Homo sapiens (Human) |
| Gene Length | 379 |
| Protein Names | Leukocyte elastase inhibitor (LEI) (Monocyte/neutrophil elastase inhibitor) (EI) (M/NEI) (Peptidase inhibitor 2) (PI-2) (Serpin B1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P30740 |
| Gene Card | SERPINB1 |
| Uniprot ID | P30740 |
| Pfam | PF00079 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | In human bone marrow, present in all CD45+ populations. Expression levels are highest in the neutrophil lineage, intermediate in monocytic, and lowest in lymphocytic lineage. Within the neutrophil lineage, expression is highest in promyelocytes. {ECO:0000269|PubMed:21248149}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4GA7 (X-ray 2.90A ) |
| DBSNP | rs34825616 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:26701651}. Cytoplasm {ECO:0000269|PubMed:23269243}. Cytolytic granule {ECO:0000269|PubMed:23269243}. Early endosome {ECO:0000269|PubMed:23269243}. |
| Mouse PG classification | NA |
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