| Gene Information | |
|---|---|
| Gene Name | MAPK3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 379 |
| Protein Names | Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1) |
| Target Name | extracellular signal-regulated kinase (erk) |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000102882 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P27361 |
| Gene Card | MAPK3 |
| Uniprot ID | P27361 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (1.780250754) |
| Ortholog in Animals | Alpaca_ MAPK3 ( ortholog_one2one ) Dog_ MAPK3 ( ortholog_one2many ) GuineaPig_ MAPK3 ( ortholog_one2one ) Macaque_ MAPK3 ( ortholog_one2one ) Mouse_ Mapk3 ( ortholog_one2one ) Pig_ MAPK3 ( ortholog_one2one ) Rat_ Mapk3 ( ortholog_one2many ) Rabbit_ MAPK3 ( ortholog_one2one ) |
| Ohnologs | MAPK1 |
| Paralogs | MAPK8, MAPK10, MAPK1, MAPK6, MAPK12, MAPK13, SRPK1, SRPK3, MAPK4, NLK, MAPK14, MOK, MAPK11, MAK, MAPK15, MAPK7, SRPK2, MAPK9, CILK1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.188975(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2ZOQ (X-ray 2.39A ) 4QTB (X-ray 1.40A ) 6GES (X-ray 2.07A ) |
| DBSNP | rs55859133 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:P21708}. Nucleus. Membrane, caveola {ECO:0000250|UniProtKB:P21708}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q63844}. Note=Autophosphorylation at Thr-207 promotes nuclear localization (PubMed:19060905). PEA15-binding redirects the biological outcome of MAPK3 kinase-signaling by sequestering MAPK3 into the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q63844, ECO:0000269|PubMed:19060905}. |
| Mouse PG classification | NA |
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