| Gene Information | |
|---|---|
| Gene Name | ATG14 |
| Organism | Homo sapiens (Human) |
| Gene Length | 492 |
| Protein Names | Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000126775 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6ZNE5 |
| Gene Card | ATG14 |
| Uniprot ID | Q6ZNE5 |
| Pfam | PF10186 |
| In ASD | no |
| Allosteric Prediction | no (-0.400497363) |
| Ortholog in Animals | Alpaca_ ATG14 ( ortholog_one2one ) Dog_ ATG14 ( ortholog_one2one ) GuineaPig_ ATG14 ( ortholog_one2one ) Macaque_ ATG14 ( ortholog_one2one ) Mouse_ Atg14 ( ortholog_one2one ) Pig_ ATG14 ( ortholog_one2one ) Rat_ Atg14 ( ortholog_one2one ) Rabbit_ ATG14 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003298(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6HOL (X-ray 1.40A ) |
| DBSNP | rs57295720 rs17675076 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19050071}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:20713597}; Peripheral membrane protein {ECO:0000305}. Preautophagosomal structure membrane {ECO:0000269|PubMed:18843052, ECO:0000269|PubMed:19050071, ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:22314358}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:25686604}; Peripheral membrane protein {ECO:0000305}. Note=Cytosolic under nutrient-rich conditions (PubMed:19050071). Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes (PubMed:19050071). Accumulates on highly curved PtdIns(3)P enriched autophagic membrane via its BATS domain to sense and maintain membrane curvature (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). {ECO:0000250|UniProtKB:Q8CDJ3}. |
| Mouse PG classification | NA |
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