| Gene Information | |
|---|---|
| Gene Name | MAPK12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 367 |
| Protein Names | Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3) |
| Target Name | mitogen-activated protein kinases |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000188130 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P53778 |
| Gene Card | MAPK12 |
| Uniprot ID | P53778 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (1.053239285) |
| Ortholog in Animals | Alpaca_ MAPK12 ( ortholog_one2one ) Dog_ MAPK12 ( ortholog_one2one ) GuineaPig_ MAPK12 ( ortholog_one2one ) Macaque_ MAPK12 ( ortholog_one2one ) Mouse_ Mapk12 ( ortholog_one2one ) Pig_ MAPK12 ( ortholog_one2one ) Rat_ Mapk12 ( ortholog_one2one ) Rabbit_ MAPK12 ( ortholog_one2one ) |
| Ohnologs | MAPK14, MAPK13 |
| Paralogs | MAPK8, MAPK10, MAPK1, MAPK6, MAPK13, SRPK1, SRPK3, MAPK4, NLK, MAPK14, MAPK3, MOK, MAPK11, MAK, MAPK15, MAPK7, SRPK2, MAPK9, CILK1 |
| Tissue | skeletal.muscle, artery |
| Tissue Specificity | Highly expressed in skeletal muscle and heart. {ECO:0000269|PubMed:11991731, ECO:0000269|PubMed:8633070}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.015867(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1CM8 (X-ray 2.40A ) 4QUM (X-ray 2.52A ) 6UNA (X-ray 2.55A ) 7CGA (X-ray 3.15A ) |
| DBSNP | rs34422484 rs35396905 rs2066776 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Mitochondrion. Note=Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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