| Gene Information | |
|---|---|
| Gene Name | MAP7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 749 |
| Protein Names | Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000135525 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q14244 |
| Gene Card | MAP7 |
| Uniprot ID | Q14244 |
| Pfam | PF05672 |
| In ASD | no |
| Allosteric Prediction | no (-0.608349771) |
| Ortholog in Animals | Alpaca_ MAP7 ( ortholog_one2one ) Dog_ MAP7 ( ortholog_one2one ) GuineaPig_ MAP7 ( ortholog_one2one ) Macaque_ MAP7 ( ortholog_one2one ) Mouse_ Map7 ( ortholog_one2one ) Pig_ MAP7 ( ortholog_one2one ) Rat_ Map7 ( ortholog_one2one ) Rabbit_ MAP7 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MAP7D1, MAP7D2, MAP7D3 |
| Tissue | NA |
| Tissue Specificity | Expressed in the skin and cells of epithelial origin. Predominantly expressed in the suprabasal layers of the normal epidermis and relatively abundant in squamous cell carcinomas but barely detectable in basal cell carcinomas. {ECO:0000269|PubMed:8408219, ECO:0000269|PubMed:9989799}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7SGS (EM 3.30A ) |
| DBSNP | rs35350783 rs35107962 rs2076190 |
| Subcellular location [CC] | Cytoplasm, perinuclear region. Basolateral cell membrane. Cytoplasm, cytoskeleton. Note=Colocalized on microtubules. An intracellular redistribution is triggered during induction of keratinocyte terminal differentiation from microtubules with a perinuclear localization to cortical microtubules organized in spike-like bundles facing intercellular contacts. |
| Mouse PG classification | NA |
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