Gene Information
Gene NameMAP6
OrganismHomo sapiens (Human)
Gene Length813
Protein NamesMicrotubule-associated protein 6 (MAP-6) (Stable tubule-only polypeptide) (STOP)
Target NameNA
Target TypeNA
Gene Age544 ( ENSG00000171533 )
Evolutionary StageEukaryota
AlphaFoldDBQ96JE9
Gene CardMAP6
Uniprot IDQ96JE9
PfamNA
In ASDno
Allosteric Predictionno (-1.073432113)
Ortholog in AnimalsAlpaca_ MAP6 ( ortholog_one2one )
Dog_ MAP6 ( ortholog_one2one )
Macaque_ MAP6 ( ortholog_one2one )
Mouse_ Map6 ( ortholog_one2one )
Pig_ MAP6 ( ortholog_one2one )
Rat_ Map6 ( ortholog_one2one )
OhnologsNA
ParalogsMAP6D1
TissueNA
Tissue SpecificityExpressed in brain (at protein level). Expressed in spinal cord. Isoform 2 expression is up-regulated in the prefrontal cortex (Brodmann's area 46) of patients with schizophrenia (postmortem brain study). {ECO:0000269|PubMed:14692697, ECO:0000269|PubMed:16624526}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs12225010 
Subcellular location [CC]Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14692697}. Golgi apparatus {ECO:0000250|UniProtKB:Q63560}. Cell projection, axon {ECO:0000250|UniProtKB:Q63560}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63560}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q63560};
Lipid-anchor {ECO:0000250|UniProtKB:Q63560};
Cytoplasmic side {ECO:0000250|UniProtKB:Q63560}. Note=Localizes predominantly in the proximal part of the axon (By similarity). Preferentially is concentrated on a portion of the microtubule polymer in which tubulin is modified by detyrosination and acetylation and is also resistant to depolymerization induced by both nocodazole and cold (By similarity). In unpolarized neurons, localizes to the Golgi and to secretory vesicles accumulating transiently at the tips of a subset of neurites (By similarity). Following neuronal polarization and during axon outgrowth, accumulates in the axonal growth cone and subsequently localizes throughout the axon (By similarity). Partially localizes to dendrites in mature neurons (By similarity). Colocalizes with neurofilament (NF)-rich inclusions in spinal cord and brain neurons of patients with amyotrophic lateral sclerosis (ALS) (PubMed:14692697). {ECO:0000250|UniProtKB:Q63560, ECO:0000269|PubMed:14692697}.
Mouse PG classificationNA
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