| Gene Information | |
|---|---|
| Gene Name | UGT1A6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 532 |
| Protein Names | UDP-glucuronosyltransferase 1-6 (UDPGT 1-6) (UGT1*6) (UGT1-06) (UGT1.6) (EC 2.4.1.17) (Phenol-metabolizing UDP-glucuronosyltransferase) (UDP-glucuronosyltransferase 1-F) (UGT-1F) (UGT1F) (UDP-glucuronosyltransferase 1A6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 3 ( ENSG00000167165 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P19224 |
| Gene Card | UGT1A6 |
| Uniprot ID | P19224 |
| Pfam | PF00201 |
| In ASD | no |
| Allosteric Prediction | yes (0.127146118) |
| Ortholog in Animals | GuineaPig_ UGT1A6 ( ortholog_one2one ) Mouse_ Ugt1a6a ( ortholog_one2many ) Mouse_ Ugt1a6b ( ortholog_one2many ) Mouse_ Ugt1a7c ( ortholog_one2many ) |
| Ohnologs | UGT2B10, UGT2A3, UGT2B28, UGT2B4, UGT2B7, UGT2A1, UGT2B15, UGT2B17, UGT2B11 |
| Paralogs | UGT2B15, UGT2B17, UGT2A3, UGT3A1, UGT1A3, UGT1A4, UGT1A5, UGT8, UGT2B4, UGT2B7, UGT3A2, UGT1A1, UGT1A10, UGT1A8, UGT1A7, UGT1A9, UGT2A1, UGT2A2, UGT2B10, UGT2B11, UGT2B28 |
| Tissue | urinary.bladder |
| Tissue Specificity | Expressed in skin. Isoforms 1 and 3 are expressed in kidney and liver. Isoform 1 but not isoform 2 is expressed in colon, esophagus and small intestine. {ECO:0000269|PubMed:1339448, ECO:0000269|PubMed:18004212}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs6759892 rs1042708 rs2070959 rs1105879 rs1042709 |
| Subcellular location [CC] | Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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