| Gene Information | |
|---|---|
| Gene Name | MAP3K8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 467 |
| Protein Names | Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2) |
| Target Name | cot oncogene messenger rna |
| Target Type | Literature-reported target |
| Gene Age | 544 ( ENSG00000107968 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P41279 |
| Gene Card | MAP3K8 |
| Uniprot ID | P41279 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.756974223) |
| Ortholog in Animals | Alpaca_ MAP3K8 ( ortholog_one2one ) Dog_ MAP3K8 ( ortholog_one2one ) GuineaPig_ MAP3K8 ( ortholog_one2one ) Macaque_ MAP3K8 ( ortholog_one2one ) Mouse_ Map3k8 ( ortholog_one2one ) Pig_ MAP3K8 ( ortholog_one2one ) Rat_ Map3k8 ( ortholog_one2one ) Rabbit_ MAP3K8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PAK5, PAK6, PAK4, SBK2, STK39, MAP4K1, PAK2, PAK1, PAK3, MINK1, TNIK, MAP4K5, SLK, MAP3K14, MAP3K19, STRADB, STK4, MAP3K1, TAOK2, MAP4K3, NRK, STRADA, MAP2K3, STK10, MAP2K6, STK26, TAOK3, TAOK1, MAP4K2, OXSR1, STK3, NEK4, STK25, STK24, MAP4K4 |
| Tissue | NA |
| Tissue Specificity | Expressed in several normal tissues and human tumor-derived cell lines. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4Y83 (X-ray 2.89A ) 4Y85 (X-ray 2.33A ) 5IU2 (X-ray 2.70A ) |
| DBSNP | rs3087944 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:8226782}. |
| Mouse PG classification | NA |
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