Gene Information
Gene NameTXNRD1
OrganismHomo sapiens (Human)
Gene Length649
Protein NamesThioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Peroxidase TXNRD1) (EC 1.11.1.2) (Thioredoxin reductase TR1)
Target Namethioredoxin reductase 1, cytoplasmic
Target TypeNA
Gene Age454 ( ENSG00000198431 )
Evolutionary StageCellular_organisms
AlphaFoldDBNA
Gene CardTXNRD1
Uniprot IDQ16881
PfamPF00462; PF07992; PF02852
In ASDno
Allosteric Predictionyes (0.69427687)
Ortholog in AnimalsAlpaca_ TXNRD1 ( ortholog_one2one )
Dog_ TXNRD1 ( ortholog_one2one )
GuineaPig_ TXNRD1 ( ortholog_one2one )
Macaque_ TXNRD1 ( ortholog_one2one )
Mouse_ Txnrd1 ( ortholog_one2one )
Pig_ TXNRD1 ( ortholog_one2one )
Rat_ Txnrd1 ( ortholog_one2one )
Rabbit_ TXNRD1 ( ortholog_one2one )
OhnologsTXNRD3
ParalogsTXNRD3, AIFM3, AIFM1, PYROXD1, DLD, TXNRD2, GSR
TissueNA
Tissue Specificity[Isoform 1]: Expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. {ECO:0000269|PubMed:18042542}.;
[Isoform 4]: Widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver. {ECO:0000269|PubMed:8999974}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2CFY  (X-ray  2.70A  )  2J3N  (X-ray  2.80A  )  2ZZ0  (X-ray  2.80A  )  2ZZB  (X-ray  3.20A  )  2ZZC  (X-ray  2.60A  )  3QFA  (X-ray  2.20A  )  3QFB  (X-ray  2.60A  ) 
DBSNP rs1127954 
Subcellular location [CC][Isoform 1]: Cytoplasm {ECO:0000269|PubMed:18042542}.;
[Isoform 4]: Cytoplasm {ECO:0000269|PubMed:15199063}. Nucleus {ECO:0000269|PubMed:15199063}.;
[Isoform 5]: Cytoplasm {ECO:0000269|PubMed:15199063}.
Mouse PG classificationNA
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