| Gene Information | |
|---|---|
| Gene Name | CDC14A |
| Organism | Homo sapiens (Human) |
| Gene Length | 594 |
| Protein Names | Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000079335 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UNH5 |
| Gene Card | CDC14A |
| Uniprot ID | Q9UNH5 |
| Pfam | PF00782; PF14671 |
| In ASD | no |
| Allosteric Prediction | no (-0.879891139) |
| Ortholog in Animals | Alpaca_ CDC14A ( ortholog_one2one ) Dog_ CDC14A ( ortholog_one2one ) GuineaPig_ CDC14A ( ortholog_one2one ) Macaque_ CDC14A ( ortholog_one2one ) Mouse_ Cdc14a ( ortholog_one2one ) Pig_ CDC14A ( ortholog_one2one ) Rat_ Cdc14a ( ortholog_one2one ) Rabbit_ CDC14A ( ortholog_one2one ) |
| Ohnologs | CDC14B |
| Paralogs | PTP4A3, CDC14B, CDC14C, PTP4A1, CDKN3, PTPDC1, PTP4A2, PALD1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs148737918 rs369245990 rs1339709390 rs28364897 rs28364923 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:9367992}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:15263015}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15263015}. Cell projection, kinocilium {ECO:0000250|UniProtKB:Q6GQT0}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q6GQT0}. Note=Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the mitotic spindle pole and at the central spindle (PubMed:12134069, PubMed:11901424, PubMed:15263015). Present along both the transient kinocilia of developing cochlear hair cells and the persistent kinocilia of vestibular hair cells (By similarity). {ECO:0000250|UniProtKB:Q6GQT0, ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069, ECO:0000269|PubMed:15263015}. |
| Mouse PG classification | NA |
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