| Gene Information | |
|---|---|
| Gene Name | MAP2K7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 419 |
| Protein Names | Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000076984 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O14733 |
| Gene Card | MAP2K7 |
| Uniprot ID | O14733 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (0.812913116) |
| Ortholog in Animals | Alpaca_ MAP2K7 ( ortholog_one2one ) Dog_ MAP2K7 ( ortholog_one2one ) GuineaPig_ MAP2K7 ( ortholog_one2one ) Mouse_ Map2k7 ( ortholog_one2one ) Pig_ MAP2K7 ( ortholog_one2one ) Rat_ Map2k7 ( ortholog_one2one ) Rabbit_ MAP2K7 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NEK1, MAP2K2, MAP2K1, MAP3K2, MAP3K4, MAP2K4, MAP3K3, MAP2K5 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle. {ECO:0000269|PubMed:16442502, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001546(Rat);0.020513(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2DYL (X-ray 2.45A ) 3WZU (X-ray 3.01A ) 4UX9 (X-ray 2.34A ) 5B2K (X-ray 2.75A ) 5B2L (X-ray 2.10A ) 5B2M (X-ray 3.06A ) 5Y8U (X-ray 2.92A ) 5Y90 (X-ray 1.30A ) 5Z1D (X-ray 2.28A ) 5Z1E (X-ray 2.30A ) 6IB0 (X-ray 2.60A ) 6IB2 (X-ray 2.10A ) 6QFL (X-ray 2.20A ) 6QFR (X-ray 2.30A ) 6QFT (X-ray 2.70A ) 6QG4 (X-ray 2.30A ) 6QG7 (X-ray 2.10A ) 6QHO (X-ray 2.70A ) 6QHR (X-ray 2.52A ) 6YFZ (X-ray 1.90A ) 6YG0 (X-ray 2.00A ) 6YG1 (X-ray 2.22A ) 6YG2 (X-ray 2.00A ) 6YG3 (X-ray 2.05A ) 6YG4 (X-ray 2.30A ) 6YG5 (X-ray 2.40A ) 6YG6 (X-ray 2.15A ) 6YG7 (X-ray 2.20A ) 6YZ4 (X-ray 1.70A ) 7CBX (X-ray 2.06A ) 7OVI (X-ray 1.95A ) 7OVJ (X-ray 2.35A ) 7OVK (X-ray 2.05A ) 7OVL (X-ray 2.90A ) 7OVM (X-ray 2.90A ) 7OVN (X-ray 2.90A ) |
| DBSNP | rs56316660 rs56106612 rs55800262 rs1053566 |
| Subcellular location [CC] | Nucleus. Cytoplasm {ECO:0000250}. |
| Mouse PG classification | NA |
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