| Gene Information | |
|---|---|
| Gene Name | MAP2K6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 334 |
| Protein Names | Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3) |
| Target Name | dual specificity mitogen-activated protein kinase kinase 6 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000108984 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P52564 |
| Gene Card | MAP2K6 |
| Uniprot ID | P52564 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.988768595) |
| Ortholog in Animals | Alpaca_ MAP2K6 ( ortholog_one2one ) Dog_ MAP2K6 ( ortholog_one2one ) GuineaPig_ MAP2K6 ( ortholog_one2one ) Macaque_ MAP2K6 ( ortholog_one2one ) Mouse_ Map2k6 ( ortholog_one2one ) Pig_ MAP2K6 ( ortholog_one2one ) Rat_ Map2k6 ( ortholog_one2one ) Rabbit_ MAP2K6 ( ortholog_one2one ) |
| Ohnologs | MAP2K3 |
| Paralogs | PAK5, PAK6, PAK4, SBK2, STK39, MAP4K1, PAK2, PAK1, PAK3, MINK1, TNIK, MAP4K5, SLK, MAP3K14, MAP3K19, STRADB, STK4, MAP3K1, TAOK2, MAP4K3, NRK, STRADA, MAP2K3, STK10, STK26, TAOK3, TAOK1, MAP3K8, MAP4K2, OXSR1, STK3, NEK4, STK25, STK24, MAP4K4 |
| Tissue | NA |
| Tissue Specificity | Isoform 2 is only expressed in skeletal muscle. Isoform 1 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas. {ECO:0000269|PubMed:8621675}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002101(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2Y8O (X-ray 1.95A ) 3ENM (X-ray 2.35A ) 3FME (X-ray 2.26A ) 3VN9 (X-ray 2.60A ) 5ETF (X-ray 2.40A ) 8A8M (EM 4.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:9768359}. Cytoplasm {ECO:0000269|PubMed:9768359}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9768359}. Note=Binds to microtubules. |
| Mouse PG classification | NA |
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