| Gene Information | |
|---|---|
| Gene Name | MAP2K5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 448 |
| Protein Names | Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5) |
| Target Name | erk activator kinase 5 |
| Target Type | Literature-reported target |
| Gene Age | 1714 ( ENSG00000137764 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13163 |
| Gene Card | MAP2K5 |
| Uniprot ID | Q13163 |
| Pfam | PF00564; PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (0.483449963) |
| Ortholog in Animals | Alpaca_ MAP2K5 ( ortholog_one2one ) Dog_ MAP2K5 ( ortholog_one2one ) GuineaPig_ MAP2K5 ( ortholog_one2one ) Macaque_ MAP2K5 ( ortholog_one2one ) Mouse_ Map2k5 ( ortholog_one2one ) Pig_ MAP2K5 ( ortholog_one2one ) Rat_ Map2k5 ( ortholog_one2one ) Rabbit_ MAP2K5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NEK1, MAP2K2, MAP2K1, MAP3K2, MAP3K4, MAP2K4, MAP3K3, MAP2K7 |
| Tissue | NA |
| Tissue Specificity | Expressed in many adult tissues. Abundant in heart and skeletal muscle. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.001990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2NPT (X-ray 1.75A ) 2O2V (X-ray 1.83A ) 4IC7 (X-ray 2.60A ) |
| DBSNP | rs56241934 rs1226964455 rs55811347 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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