Gene Information | |
---|---|
Gene Name | PRSET7 |
Organism | Homo sapiens (Human) |
Gene Length | 393 |
Protein Names | N-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.361) (Lysine N-methyltransferase 5A) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8) |
Target Name | NA |
Target Type | NA |
Gene Age | NA |
Evolutionary Stage | NA |
AlphaFoldDB | Q9NQR1 |
Gene Card | KMT5A |
Uniprot ID | Q9NQR1 |
Pfam | PF00856 |
In ASD | yes |
Allosteric Prediction | NA |
Ortholog in Animals | NA |
Ohnologs | NA |
Paralogs | NA |
Tissue | NA |
Tissue Specificity | NA |
Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002101(Rat);NULL(Rabbit) |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
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Gene Ontology (molecular function) |
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PDB | 1ZKK (X-ray 1.45A ) 2BQZ (X-ray 1.50A ) 3F9W (X-ray 1.60A ) 3F9X (X-ray 1.25A ) 3F9Y (X-ray 1.50A ) 3F9Z (X-ray 1.60A ) 4IJ8 (X-ray 2.00A ) 5HQ2 (X-ray 4.50A ) 5T5G (X-ray 2.10A ) 5TEG (X-ray 1.30A ) 5TH7 (X-ray 1.95A ) 5V2N (X-ray 2.00A ) 5W1Y (X-ray 1.70A ) 6BOZ (X-ray 2.40A ) 7D1Z (EM 3.15A ) 7D20 (EM 3.00A ) 7XPX (EM 3.20A ) |
DBSNP | NA |
Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12086618}. Chromosome {ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:12208845, ECO:0000269|PubMed:23468428}. Note=Specifically localizes to mitotic chromosomes (PubMed:12208845). Colocalized with SIRT2 at mitotic foci (PubMed:23468428). Associates with chromosomes during mitosis; association is increased in a H(2)O(2)-induced oxidative stress-dependent manner (PubMed:23468428). Associates with silent chromatin on euchromatic arms (PubMed:12086618). Not associated with constitutive heterochromatin (PubMed:12086618). {ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:12208845, ECO:0000269|PubMed:23468428}. |
Mouse PG classification | NA |
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