Gene Information
Gene NamePRSET7
OrganismHomo sapiens (Human)
Gene Length393
Protein NamesN-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.361) (Lysine N-methyltransferase 5A) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ9NQR1
Gene CardKMT5A
Uniprot IDQ9NQR1
PfamPF00856
In ASDyes
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.002101(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1ZKK  (X-ray  1.45A  2BQZ  (X-ray  1.50A  3F9W  (X-ray  1.60A  3F9X  (X-ray  1.25A  3F9Y  (X-ray  1.50A  3F9Z  (X-ray  1.60A  4IJ8  (X-ray  2.00A  5HQ2  (X-ray  4.50A  5T5G  (X-ray  2.10A  5TEG  (X-ray  1.30A  5TH7  (X-ray  1.95A  5V2N  (X-ray  2.00A  5W1Y  (X-ray  1.70A  6BOZ  (X-ray  2.40A  7D1Z  (EM  3.15A  7D20  (EM  3.00A  7XPX  (EM  3.20A 
DBSNP NA 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:12086618}. Chromosome {ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:12208845, ECO:0000269|PubMed:23468428}. Note=Specifically localizes to mitotic chromosomes (PubMed:12208845). Colocalized with SIRT2 at mitotic foci (PubMed:23468428). Associates with chromosomes during mitosis;
association is increased in a H(2)O(2)-induced oxidative stress-dependent manner (PubMed:23468428). Associates with silent chromatin on euchromatic arms (PubMed:12086618). Not associated with constitutive heterochromatin (PubMed:12086618). {ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:12208845, ECO:0000269|PubMed:23468428}.
Mouse PG classificationNA
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