| Gene Information | |
|---|---|
| Gene Name | MAOA |
| Organism | Homo sapiens (Human) |
| Gene Length | 527 |
| Protein Names | Amine oxidase [flavin-containing] A (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A) |
| Target Name | monoamine oxidase type a |
| Target Type | Successful target |
| Gene Age | 1714 ( ENSG00000189221 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P21397 |
| Gene Card | MAOA |
| Uniprot ID | P21397 |
| Pfam | PF01593 |
| In ASD | yes |
| Allosteric Prediction | yes (1.038476614) |
| Ortholog in Animals | Alpaca_ MAOA ( ortholog_one2one ) Dog_ MAOA ( ortholog_one2one ) GuineaPig_ MAOA ( ortholog_one2one ) Macaque_ MAOA ( ortholog_one2one ) Mouse_ Maoa ( ortholog_one2one ) Rat_ Maoa ( ortholog_one2one ) Rabbit_ MAOA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KDM1A, SMOX, PPOX, KDM1B, PAOX, MAOB, IL4I1 |
| Tissue | NA |
| Tissue Specificity | Heart, liver, duodenum, blood vessels and kidney. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.2(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2BXR (X-ray 3.00A ) 2BXS (X-ray 3.15A ) 2Z5X (X-ray 2.20A ) 2Z5Y (X-ray 2.17A ) |
| DBSNP | rs77698881 rs587777457 rs1799835 rs1800466 |
| Subcellular location [CC] | Mitochondrion outer membrane {ECO:0000250|UniProtKB:P21396}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:P21396}; Cytoplasmic side {ECO:0000250|UniProtKB:P21396}. |
| Mouse PG classification | HPG |
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