| Gene Information | |
|---|---|
| Gene Name | MANEA |
| Organism | Homo sapiens (Human) |
| Gene Length | 462 |
| Protein Names | Glycoprotein endo-alpha-1,2-mannosidase (Endo-alpha mannosidase) (Endomannosidase) (hEndo) (EC 3.2.1.130) (Mandaselin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000172469 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q5SRI9 |
| Gene Card | MANEA |
| Uniprot ID | Q5SRI9 |
| Pfam | PF16317 |
| In ASD | no |
| Allosteric Prediction | no (-0.978744828) |
| Ortholog in Animals | Alpaca_ MANEA ( ortholog_one2one ) Dog_ MANEA ( ortholog_one2one ) GuineaPig_ MANEA ( ortholog_one2one ) Macaque_ MANEA ( ortholog_one2one ) Mouse_ Manea ( ortholog_one2one ) Pig_ MANEA ( ortholog_one2one ) Rat_ Manea ( ortholog_one2one ) |
| Ohnologs | MANEAL |
| Paralogs | MANEAL |
| Tissue | NA |
| Tissue Specificity | Highly expressed in the liver and kidney. Expressed at lower levels in muscle, pancreas, heart, placenta, lung and brain. {ECO:0000269|PubMed:15677381}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6ZDC (X-ray 2.25A ) 6ZDF (X-ray 3.00A ) 6ZDK (X-ray 2.00A ) 6ZDL (X-ray 1.90A ) 6ZFA (X-ray 1.80A ) 6ZFN (X-ray 1.10A ) 6ZFQ (X-ray 1.20A ) 6ZJ1 (X-ray 1.96A ) 6ZJ5 (X-ray 2.27A ) |
| DBSNP | rs780723017 |
| Subcellular location [CC] | Golgi apparatus membrane {ECO:0000269|PubMed:15677381, ECO:0000269|PubMed:15760709}; Single-pass type II membrane protein {ECO:0000269|PubMed:15677381, ECO:0000269|PubMed:15760709}. |
| Mouse PG classification | NA |
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