Gene Information
Gene NameTIGAR
OrganismHomo sapiens (Human)
Gene Length270
Protein NamesFructose-2,6-bisphosphatase TIGAR (EC 3.1.3.46) (TP53-induced glycolysis and apoptosis regulator) (TP53-induced glycolysis regulatory phosphatase)
Target NameNA
Target TypeNA
Gene Age332 ( ENSG00000078237 )
Evolutionary StageCellular_organisms
AlphaFoldDBQ9NQ88
Gene CardTIGAR
Uniprot IDQ9NQ88
PfamPF00300
In ASDno
Allosteric Predictionyes (0.509479567)
Ortholog in AnimalsAlpaca_ TIGAR ( ortholog_one2one )
Dog_ TIGAR ( ortholog_one2one )
GuineaPig_ TIGAR ( ortholog_one2one )
Macaque_ TIGAR ( ortholog_one2one )
Mouse_ Tigar ( ortholog_one2one )
Pig_ TIGAR ( ortholog_one2one )
Rat_ RGD1308005 ( ortholog_one2many )
Rat_ Tigar ( ortholog_one2many )
Rabbit_ TIGAR ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityExpressed in the brain (PubMed:22887998). Expressed in breast tumors (PubMed:21820150). Expressed in glioblastomas (PubMed:22887998). {ECO:0000269|PubMed:21820150, ECO:0000269|PubMed:22887998}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3DCY  (X-ray  1.75A  ) 
DBSNP NA 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:25928429}. Nucleus {ECO:0000269|PubMed:25928429}. Mitochondrion {ECO:0000269|PubMed:23185017}. Note=Translocated to the mitochondria during hypoxia in a HIF1A-dependent manner (PubMed:23185017). Colocalizes with HK2 in the mitochondria during hypoxia (PubMed:23185017). Translocated to the nucleus during hypoxia and/or genome stress-induced DNA damage responses in cancer cells (PubMed:25928429). Translocation to the mitochondria is enhanced in ischemic cortex after reperfusion and/or during oxygen and glucose deprivation (OGD)/reoxygenation insult in primary neurons (By similarity). {ECO:0000250|UniProtKB:Q8BZA9, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:25928429}.
Mouse PG classificationNA
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