| Gene Information | |
|---|---|
| Gene Name | MATE2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 602 |
| Protein Names | Multidrug and toxin extrusion protein 2 (MATE-2) (hMATE-2) (Kidney-specific H(+)/organic cation antiporter) (Solute carrier family 47 member 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q86VL8 |
| Gene Card | SLC47A2 |
| Uniprot ID | Q86VL8 |
| Pfam | PF01554 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | [Isoform 1]: High expression in kidney. Very small expression in adrenal gland and lung. {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:21419862}.; [Isoform 3]: High expression in kidney. Very small expression in brain and testis. {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:21419862}.; [Isoform 6]: Ubiquitously expressed in all tissues examined except the kidney. {ECO:0000269|PubMed:16807400}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34399035 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19158817}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:16807400, ECO:0000269|PubMed:21419862}; Multi-pass membrane protein {ECO:0000255}. Note=Detected in the renal urinary tubules. {ECO:0000269|PubMed:21419862}.; [Isoform 6]: Apical cell membrane {ECO:0000269|PubMed:16807400}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at the brush border membranes of the proximal tubules. {ECO:0000269|PubMed:16807400}. |
| Mouse PG classification | NA |
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